Are the Powerpuff Girls hooked on E?
Hell no!
Of course, that's not much of an argument, so I'll quote from someone who puts it all in perfect perspective:
"They're SD Sailor scouts, for Pete's sake! Nobody fights crime on 'e'. You hug it, jump around like a moron and quietly brain-bleed for a few hours after the hydrogen peroxide effect kicks in. Sheesh. If the PPG girls were taking 'e', they'd be more like hyper Care Bears with that popular 'strug-out Monday' look. Subtle difference, I realize, but you don't see too many well delivered flying kicks at the average rave." Fantastic Lad (kuro5hin.org)
I think that covers the issue very nicely.