I finally attended the Boston Python Meetup monthly meeting. Nate did a presentation on ArchGenXML for building archetypes in Plone. I have no Plone/ZOPE experience, though I do know what they are and I've followed the projects for a bit. The presentation was really interesting and definitely broke the Plone/ZOPE ice for me.
The Boston Python Interest Group (Boston-PIG) no longer uses Meetup. The web-site for the group is now at http://wiki.python.org/moin/BostonPig.