If you're one of the lucky people going to PyCon 2010, you might want to spend some time coming up to speed on some of the talks being given.
Interested in the GIL? David Beazley is giving a talk on the inner workings of the Python GIL. He's given several GIL-related presentations before: Asynchronous vs. Threaded Python, Mindblowing Python GIL, and Changes to the GIL in Python 3.
Interested in documentation? Wesleay J. Chun is giving a talk on writing books using Python and Open Source Software. This will likely talk about Sphinx. Take some time to watch Brandon Rhodes talk about Sphinx at PyAtl.
Don't go to PyCon unprepared!